Absent C3a and C5a receptor signaling into CD4(+) T cells enables auto-inductive TGF-β1 signaling and induction of Foxp3(+) T regulatory cells

C3a and C5a receptor (C3aR and C5aR) signaling by dendritic cells and CD4(+) cells provides costimulatory and survival signals to T effector cells. Here, we demonstrate that when C3aR and C5aR signals are not transduced into CD4(+) cells, PI-3Kγ-AKT-mTOR signaling ceases, PKA activation increases, a...

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Detalles Bibliográficos
Autores principales: Strainic, Michael G., Shevach, Ethan M., An, Fengqi, Lin, Feng, Medof, M. Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144047/
https://www.ncbi.nlm.nih.gov/pubmed/23263555
http://dx.doi.org/10.1038/ni.2499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144047/
https://www.ncbi.nlm.nih.gov/pubmed/23263555
http://dx.doi.org/10.1038/ni.2499

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