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Absent C3a and C5a receptor signaling into CD4(+) T cells enables auto-inductive TGF-β1 signaling and induction of Foxp3(+) T regulatory cells
C3a and C5a receptor (C3aR and C5aR) signaling by dendritic cells and CD4(+) cells provides costimulatory and survival signals to T effector cells. Here, we demonstrate that when C3aR and C5aR signals are not transduced into CD4(+) cells, PI-3Kγ-AKT-mTOR signaling ceases, PKA activation increases, a...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144047/ https://www.ncbi.nlm.nih.gov/pubmed/23263555 http://dx.doi.org/10.1038/ni.2499 |