Folding similarity of the outer pore region in prokaryotic and eukaryotic sodium channels revealed by docking of conotoxins GIIIA, PIIIA, and KIIIA in a NavAb-based model of Nav1.4

Voltage-gated sodium channels are targets for many drugs and toxins. However, the rational design of medically relevant channel modulators is hampered by the lack of x-ray structures of eukaryotic channels. Here, we used a homology model based on the x-ray structure of the NavAb prokaryotic sodium c...

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Detalles Bibliográficos
Autores principales: Korkosh, Viacheslav S., Zhorov, Boris S., Tikhonov, Denis B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144674/
https://www.ncbi.nlm.nih.gov/pubmed/25156117
http://dx.doi.org/10.1085/jgp.201411226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144674/
https://www.ncbi.nlm.nih.gov/pubmed/25156117
http://dx.doi.org/10.1085/jgp.201411226

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