Natural Antisense Inhibition Results in Transcriptional De-Repression and Gene Upregulation

Here we demonstrate that natural antisense transcripts (NATs), which are abundant in mammalian genomes, can function as repressors of specific genomic loci and that their removal or inhibition by AntagoNAT oligonucleotides leads to transient and reversible upregulation of sense gene expression. As o...

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Detalles Bibliográficos
Autores principales: Modarresi, Farzaneh, Faghihi, Mohammad Ali, Lopez-Toledano, Miguel A., Fatemi, Roya Pedram, Magistri, Marco, Brothers, Shaun P., van der Brug, Marcel P., Wahlestedt, Claes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144683/
https://www.ncbi.nlm.nih.gov/pubmed/22446693
http://dx.doi.org/10.1038/nbt.2158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144683/
https://www.ncbi.nlm.nih.gov/pubmed/22446693
http://dx.doi.org/10.1038/nbt.2158

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