Neuroinflammation and neurologic deficits in diabetes linked to brain accumulation of amylin

BACKGROUND: We recently found that brain tissue from patients with type-2 diabetes (T2D) and cognitive impairment contains deposits of amylin, an amyloidogenic hormone synthesized and co-secreted with insulin by pancreatic β-cells. Amylin deposition is promoted by chronic hypersecretion of amylin (h...

Descripción completa

Detalles Bibliográficos
Autores principales: Srodulski, Sarah, Sharma, Savita, Bachstetter, Adam B, Brelsfoard, Jennifer M, Pascual, Conrado, Xie, Xinmin Simon, Saatman, Kathryn E, Van Eldik, Linda J, Despa, Florin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144699/
https://www.ncbi.nlm.nih.gov/pubmed/25149184
http://dx.doi.org/10.1186/1750-1326-9-30

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144699/
https://www.ncbi.nlm.nih.gov/pubmed/25149184
http://dx.doi.org/10.1186/1750-1326-9-30

Ejemplares similares