The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation

Neutrophils are the first line of cellular defense in response to infections and inflammatory injuries. However, neutrophil activation and accumulation into tissues trigger tissue damage due to release of a plethora of toxic oxidants and proteases, a cause of acute lung injury (ALI). Despite its cli...

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Detalles Bibliográficos
Autores principales: Kumar, Sachin, Xu, Juying, Kumar, Rupali Sani, Lakshmikanthan, Sribalaji, Kapur, Reuben, Kofron, Matthew, Chrzanowska-Wodnicka, Magdalena, Filippi, Marie-Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144729/
https://www.ncbi.nlm.nih.gov/pubmed/25092872
http://dx.doi.org/10.1084/jem.20131706

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144729/
https://www.ncbi.nlm.nih.gov/pubmed/25092872
http://dx.doi.org/10.1084/jem.20131706

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