Mechanisms of action of therapeutic amyloidogenic hexapeptides in amelioration of inflammatory brain disease

Amyloid fibrils composed of peptides as short as six amino acids are effective therapeutics for experimental autoimmune encephalomyelitis (EAE). Immunosuppression arises from at least two pathways: (1) expression of type 1 IFN by pDCs, which were induced by neutrophil extracellular traps arising fro...

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Detalles Bibliográficos
Autores principales: Kurnellas, Michael P., Schartner, Jill M., Fathman, C. Garrison, Jagger, Ann, Steinman, Lawrence, Rothbard, Jonathan B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144739/
https://www.ncbi.nlm.nih.gov/pubmed/25073790
http://dx.doi.org/10.1084/jem.20140107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144739/
https://www.ncbi.nlm.nih.gov/pubmed/25073790
http://dx.doi.org/10.1084/jem.20140107

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