Evolution of Pre-Existing versus Acquired Resistance to Platinum Drugs and PARP Inhibitors in BRCA-Associated Cancers

Platinum drugs and PARP inhibitors (“PARPis”) are considered to be effective in BRCA-associated cancers with impaired DNA repair. These agents cause stalled and collapsed replication forks and create double-strand breaks effectively in the absence of repair mechanisms, resulting in arrest of the cel...

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Detalles Bibliográficos
Autores principales: Yamamoto, Kimiyo N., Hirota, Kouji, Takeda, Shunichi, Haeno, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144917/
https://www.ncbi.nlm.nih.gov/pubmed/25158060
http://dx.doi.org/10.1371/journal.pone.0105724

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144917/
https://www.ncbi.nlm.nih.gov/pubmed/25158060
http://dx.doi.org/10.1371/journal.pone.0105724

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