Vitamin E Dietary Supplementation Improves Neurological Symptoms and Decreases c-Abl/p73 Activation in Niemann-Pick C Mice

Niemann-Pick C (NPC) disease is a fatal neurodegenerative disorder characterized by the accumulation of free cholesterol in lysosomes. We have previously reported that oxidative stress is the main upstream stimulus activating the proapoptotic c-Abl/p73 pathway in NPC neurons. We have also observed a...

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Detalles Bibliográficos
Autores principales: Marín, Tamara, Contreras, Pablo, Castro, Juan Francisco, Chamorro, David, Balboa, Elisa, Bosch-Morató, Mònica, Muñoz, Francisco J., Alvarez, Alejandra R., Zanlungo, Silvana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145291/
https://www.ncbi.nlm.nih.gov/pubmed/25079853
http://dx.doi.org/10.3390/nu6083000

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145291/
https://www.ncbi.nlm.nih.gov/pubmed/25079853
http://dx.doi.org/10.3390/nu6083000

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