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E-Cadherin and Gastric Cancer: Cause, Consequence, and Applications

E-cadherin (epithelial-cadherin), encoded by the CDH1 gene, is a transmembrane glycoprotein playing a crucial role in maintaining cell-cell adhesion. E-cadherin has been reported to be a tumor suppressor and to be down regulated in gastric cancer. Besides genetic mutations in CDH1 gene to induce her...

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Detalles Bibliográficos
Autores principales: Liu, Xin, Chu, Kent-Man
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145387/
https://www.ncbi.nlm.nih.gov/pubmed/25184143
http://dx.doi.org/10.1155/2014/637308
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author Liu, Xin
Chu, Kent-Man
author_facet Liu, Xin
Chu, Kent-Man
author_sort Liu, Xin
collection PubMed
description E-cadherin (epithelial-cadherin), encoded by the CDH1 gene, is a transmembrane glycoprotein playing a crucial role in maintaining cell-cell adhesion. E-cadherin has been reported to be a tumor suppressor and to be down regulated in gastric cancer. Besides genetic mutations in CDH1 gene to induce hereditary diffuse gastric cancer (HDGC), epigenetic factors such as DNA hypermethylation also contribute to the reduction of E-cadherin in gastric carcinogenesis. In addition, expression of E-cadherin could be mediated by infectious agents such as H. pylori (Helicobacter pylori). As E-cadherin is vitally involved in signaling pathways modulating cell proliferation, survival, invasion, and migration, dysregulation of E-cadherin leads to dysfunction of gastric epithelial cells and contributes to gastric cancer development. Moreover, changes in its expression could reflect pathological conditions of gastric mucosa, making its role in gastric cancer complicated. In this review, we summarize the functions of E-cadherin and the signaling pathways it regulates. We aim to provide comprehensive perspectives in the molecular mechanism of E-cadherin and its involvement in gastric cancer initiation and progression. We also focus on its applications for early diagnosis, prognosis, and therapy in gastric cancer in order to open new avenues in this field.
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spelling pubmed-41453872014-09-02 E-Cadherin and Gastric Cancer: Cause, Consequence, and Applications Liu, Xin Chu, Kent-Man Biomed Res Int Review Article E-cadherin (epithelial-cadherin), encoded by the CDH1 gene, is a transmembrane glycoprotein playing a crucial role in maintaining cell-cell adhesion. E-cadherin has been reported to be a tumor suppressor and to be down regulated in gastric cancer. Besides genetic mutations in CDH1 gene to induce hereditary diffuse gastric cancer (HDGC), epigenetic factors such as DNA hypermethylation also contribute to the reduction of E-cadherin in gastric carcinogenesis. In addition, expression of E-cadherin could be mediated by infectious agents such as H. pylori (Helicobacter pylori). As E-cadherin is vitally involved in signaling pathways modulating cell proliferation, survival, invasion, and migration, dysregulation of E-cadherin leads to dysfunction of gastric epithelial cells and contributes to gastric cancer development. Moreover, changes in its expression could reflect pathological conditions of gastric mucosa, making its role in gastric cancer complicated. In this review, we summarize the functions of E-cadherin and the signaling pathways it regulates. We aim to provide comprehensive perspectives in the molecular mechanism of E-cadherin and its involvement in gastric cancer initiation and progression. We also focus on its applications for early diagnosis, prognosis, and therapy in gastric cancer in order to open new avenues in this field. Hindawi Publishing Corporation 2014 2014-08-12 /pmc/articles/PMC4145387/ /pubmed/25184143 http://dx.doi.org/10.1155/2014/637308 Text en Copyright © 2014 X. Liu and K.-M. Chu. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Liu, Xin
Chu, Kent-Man
E-Cadherin and Gastric Cancer: Cause, Consequence, and Applications
title E-Cadherin and Gastric Cancer: Cause, Consequence, and Applications
title_full E-Cadherin and Gastric Cancer: Cause, Consequence, and Applications
title_fullStr E-Cadherin and Gastric Cancer: Cause, Consequence, and Applications
title_full_unstemmed E-Cadherin and Gastric Cancer: Cause, Consequence, and Applications
title_short E-Cadherin and Gastric Cancer: Cause, Consequence, and Applications
title_sort e-cadherin and gastric cancer: cause, consequence, and applications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145387/
https://www.ncbi.nlm.nih.gov/pubmed/25184143
http://dx.doi.org/10.1155/2014/637308
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