A tethered delivery mechanism explains the catalytic action of a microtubule polymerase

Stu2p/XMAP215 proteins are essential microtubule polymerases that use multiple αβ-tubulin-interacting TOG domains to bind microtubule plus ends and catalyze fast microtubule growth. We report here the structure of the TOG2 domain from Stu2p bound to yeast αβ-tubulin. Like TOG1, TOG2 binds selectivel...

Descripción completa

Detalles Bibliográficos
Autores principales: Ayaz, Pelin, Munyoki, Sarah, Geyer, Elisabeth A, Piedra, Felipe-Andrés, Vu, Emily S, Bromberg, Raquel, Otwinowski, Zbyszek, Grishin, Nick V, Brautigam, Chad A, Rice, Luke M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145800/
https://www.ncbi.nlm.nih.gov/pubmed/25097237
http://dx.doi.org/10.7554/eLife.03069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145800/
https://www.ncbi.nlm.nih.gov/pubmed/25097237
http://dx.doi.org/10.7554/eLife.03069

Ejemplares similares