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A tethered delivery mechanism explains the catalytic action of a microtubule polymerase
Stu2p/XMAP215 proteins are essential microtubule polymerases that use multiple αβ-tubulin-interacting TOG domains to bind microtubule plus ends and catalyze fast microtubule growth. We report here the structure of the TOG2 domain from Stu2p bound to yeast αβ-tubulin. Like TOG1, TOG2 binds selectivel...
Autores principales: | Ayaz, Pelin, Munyoki, Sarah, Geyer, Elisabeth A, Piedra, Felipe-Andrés, Vu, Emily S, Bromberg, Raquel, Otwinowski, Zbyszek, Grishin, Nick V, Brautigam, Chad A, Rice, Luke M |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145800/ https://www.ncbi.nlm.nih.gov/pubmed/25097237 http://dx.doi.org/10.7554/eLife.03069 |
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