Pharmacokinetics and bioavailability of oxycodone and acetaminophen following single-dose administration of MNK-795, a dual-layer biphasic IR/ER combination formulation, under fed and fasted conditions

BACKGROUND: XARTEMIS™ XR (formerly MNK-795) is a combination oxycodone (OC) and acetaminophen (APAP) analgesic with both immediate-release and extended-release (ER) components (ER OC/APAP). The tablets are designed with gastric-retentive ER oral delivery technology that releases the ER component at...

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Detalles Bibliográficos
Autores principales: Devarakonda, Krishna, Morton, Terri, Margulis, Rachel, Giuliani, Michael, Barrett, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145823/
https://www.ncbi.nlm.nih.gov/pubmed/25170252
http://dx.doi.org/10.2147/DDDT.S64261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145823/
https://www.ncbi.nlm.nih.gov/pubmed/25170252
http://dx.doi.org/10.2147/DDDT.S64261

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