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Divalent cation tolerance protein binds to β-secretase and inhibits the processing of amyloid precursor protein☆
The deposition of amyloid-beta is a pathological hallmark of Alzheimer's disease. Amyloid-beta is derived from amyloid precursor protein through sequential proteolytic cleavages by β-secretase (beta-site amyloid precursor protein-cleaving enzyme 1) and γ-secretase. To further elucidate the role...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145881/ https://www.ncbi.nlm.nih.gov/pubmed/25206392 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.11.004 |