Autophagy and neurodegenerative disorders

Accumulation of aberrant proteins and inclusion bodies are hallmarks in most neurodegenerative diseases. Consequently, these aggregates within neurons lead to toxic effects, overproduction of reactive oxygen species and oxidative stress. Autophagy is a significant intracellular mechanism that remove...

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Detalles Bibliográficos
Autores principales: Kesidou, Evangelia, Lagoudaki, Roza, Touloumi, Olga, Poulatsidou, Kyriaki-Nefeli, Simeonidou, Constantina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146038/
https://www.ncbi.nlm.nih.gov/pubmed/25206537
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.24.007
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author Kesidou, Evangelia
Lagoudaki, Roza
Touloumi, Olga
Poulatsidou, Kyriaki-Nefeli
Simeonidou, Constantina
author_facet Kesidou, Evangelia
Lagoudaki, Roza
Touloumi, Olga
Poulatsidou, Kyriaki-Nefeli
Simeonidou, Constantina
author_sort Kesidou, Evangelia
collection PubMed
description Accumulation of aberrant proteins and inclusion bodies are hallmarks in most neurodegenerative diseases. Consequently, these aggregates within neurons lead to toxic effects, overproduction of reactive oxygen species and oxidative stress. Autophagy is a significant intracellular mechanism that removes damaged organelles and misfolded proteins in order to maintain cell homeostasis. Excessive or insufficient autophagic activity in neurons leads to altered homeostasis and influences their survival rate, causing neurodegeneration. The review article provides an update of the role of autophagic process in representative chronic and acute neurodegenerative disorders.
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spelling pubmed-41460382014-09-09 Autophagy and neurodegenerative disorders Kesidou, Evangelia Lagoudaki, Roza Touloumi, Olga Poulatsidou, Kyriaki-Nefeli Simeonidou, Constantina Neural Regen Res Review Article Accumulation of aberrant proteins and inclusion bodies are hallmarks in most neurodegenerative diseases. Consequently, these aggregates within neurons lead to toxic effects, overproduction of reactive oxygen species and oxidative stress. Autophagy is a significant intracellular mechanism that removes damaged organelles and misfolded proteins in order to maintain cell homeostasis. Excessive or insufficient autophagic activity in neurons leads to altered homeostasis and influences their survival rate, causing neurodegeneration. The review article provides an update of the role of autophagic process in representative chronic and acute neurodegenerative disorders. Medknow Publications & Media Pvt Ltd 2013-08-25 /pmc/articles/PMC4146038/ /pubmed/25206537 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.24.007 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kesidou, Evangelia
Lagoudaki, Roza
Touloumi, Olga
Poulatsidou, Kyriaki-Nefeli
Simeonidou, Constantina
Autophagy and neurodegenerative disorders
title Autophagy and neurodegenerative disorders
title_full Autophagy and neurodegenerative disorders
title_fullStr Autophagy and neurodegenerative disorders
title_full_unstemmed Autophagy and neurodegenerative disorders
title_short Autophagy and neurodegenerative disorders
title_sort autophagy and neurodegenerative disorders
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146038/
https://www.ncbi.nlm.nih.gov/pubmed/25206537
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.24.007
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AT poulatsidoukyriakinefeli autophagyandneurodegenerativedisorders
AT simeonidouconstantina autophagyandneurodegenerativedisorders

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