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Nasal mucosal inhalation of amyloid-beta peptide 3–10 defective adenovirus attenuates cytotoxicity induced by beta-amyloid (1–42)

Three-month-old Alzheimer's disease model transgenic mice were immunized with Aβ(1–42) Plp-Adenovirus [Ad]-X-CMV-(Aβ(3–10))(10)-CpG [AdCpG-(Aβ(3–10))(10)] or AdCpG virus fluid via nasal mucosal inhalation, respectively. ELISA analysis of serum showed Aβ(42) antibody titers were significantly in...

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Detalles Bibliográficos
Autores principales: Jiang, Tongzi, Guo, Wanshu, Sha, Sha, Xing, Xiaona, Guo, Rong, Cao, Yunpeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146261/
https://www.ncbi.nlm.nih.gov/pubmed/25206904
http://dx.doi.org/10.4103/1673-5374.131605