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Sweet taste sensitivity in pre-diabetics, diabetics and normoglycemic controls: a comparative cross sectional study
BACKGROUND: Increasing prevalence of pre-diabetes is an emerging public health problem. Decrease in sweet taste sensitivity which can lead to an increase in sugar intake might be a factor driving them to overt diabetes. The aim of the present study was to assess the sweet taste sensitivity in pre-di...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146442/ https://www.ncbi.nlm.nih.gov/pubmed/25123551 http://dx.doi.org/10.1186/1472-6823-14-67 |
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author | Wasalathanthri, Sudharshani Hettiarachchi, Priyadarshika Prathapan, Shamini |
author_facet | Wasalathanthri, Sudharshani Hettiarachchi, Priyadarshika Prathapan, Shamini |
author_sort | Wasalathanthri, Sudharshani |
collection | PubMed |
description | BACKGROUND: Increasing prevalence of pre-diabetes is an emerging public health problem. Decrease in sweet taste sensitivity which can lead to an increase in sugar intake might be a factor driving them to overt diabetes. The aim of the present study was to assess the sweet taste sensitivity in pre-diabetics in comparison with diabetics and with normoglycemic controls. METHODS: Forty pre-diabetics, 40 diabetics and 34 normoglycemic controls were studied. The three groups were matched for age, sex and BMI. The division into groups was based on their glycated hemoglobin levels. The detection and recognition thresholds were determined by the multiple forced-choice method using sucrose solutions prepared in ¼ log dilutions. The intensities of perceived sensations for a series of suprathreshold concentrations of sucrose solutions prepared in ½ log dilution were determined by rating on a visual analogue scale. Statistical analyses were performed by SPSS version 21. RESULTS: The mean (SD) detection thresholds of diabetic, pre-diabetic and normoglycemic groups were 0.025 (0.01), 0.018 (0.01) and 0.015 (0.01) respectively with a significant increase in diabetic group compared to normoglycemic group (p = 0.03). The mean recognition thresholds were not different among the three groups. When the intensity ratings for suprathreshold concentrations of sucrose were compared between the three groups, for all suprathreshold concentrations tested, significant differences were observed across the four concentrations (p < 0.001) and between groups in suprathreshold ratings (p < 0.05). Further analysis showed that the diabetic group had significantly lower suprathreshold ratings than the normoglycemic group (p < 0.001). Although all mean suprathreshold intensity ratings of the pre-diabetic group were between the normoglycemic and diabetic groups, the differences were not significant. CONCLUSIONS: This is the first study to demonstrate the sweet taste sensitivity in pre-diabetics. The findings of the present study do not support the hypothesis of decreased sweet taste sensitivity of pre-diabetics. However, the results confirm the previous findings of blunted taste response in diabetics. The observation of pre-diabetics having intermediate values for all taste thresholds and suprathreshold ratings warrants a future investigation with a larger pre-diabetic sample recruited with more specific screening criteria to test this hypothesis further. |
format | Online Article Text |
id | pubmed-4146442 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-41464422014-08-28 Sweet taste sensitivity in pre-diabetics, diabetics and normoglycemic controls: a comparative cross sectional study Wasalathanthri, Sudharshani Hettiarachchi, Priyadarshika Prathapan, Shamini BMC Endocr Disord Research Article BACKGROUND: Increasing prevalence of pre-diabetes is an emerging public health problem. Decrease in sweet taste sensitivity which can lead to an increase in sugar intake might be a factor driving them to overt diabetes. The aim of the present study was to assess the sweet taste sensitivity in pre-diabetics in comparison with diabetics and with normoglycemic controls. METHODS: Forty pre-diabetics, 40 diabetics and 34 normoglycemic controls were studied. The three groups were matched for age, sex and BMI. The division into groups was based on their glycated hemoglobin levels. The detection and recognition thresholds were determined by the multiple forced-choice method using sucrose solutions prepared in ¼ log dilutions. The intensities of perceived sensations for a series of suprathreshold concentrations of sucrose solutions prepared in ½ log dilution were determined by rating on a visual analogue scale. Statistical analyses were performed by SPSS version 21. RESULTS: The mean (SD) detection thresholds of diabetic, pre-diabetic and normoglycemic groups were 0.025 (0.01), 0.018 (0.01) and 0.015 (0.01) respectively with a significant increase in diabetic group compared to normoglycemic group (p = 0.03). The mean recognition thresholds were not different among the three groups. When the intensity ratings for suprathreshold concentrations of sucrose were compared between the three groups, for all suprathreshold concentrations tested, significant differences were observed across the four concentrations (p < 0.001) and between groups in suprathreshold ratings (p < 0.05). Further analysis showed that the diabetic group had significantly lower suprathreshold ratings than the normoglycemic group (p < 0.001). Although all mean suprathreshold intensity ratings of the pre-diabetic group were between the normoglycemic and diabetic groups, the differences were not significant. CONCLUSIONS: This is the first study to demonstrate the sweet taste sensitivity in pre-diabetics. The findings of the present study do not support the hypothesis of decreased sweet taste sensitivity of pre-diabetics. However, the results confirm the previous findings of blunted taste response in diabetics. The observation of pre-diabetics having intermediate values for all taste thresholds and suprathreshold ratings warrants a future investigation with a larger pre-diabetic sample recruited with more specific screening criteria to test this hypothesis further. BioMed Central 2014-08-13 /pmc/articles/PMC4146442/ /pubmed/25123551 http://dx.doi.org/10.1186/1472-6823-14-67 Text en Copyright © 2014 Wasalathanthri et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Wasalathanthri, Sudharshani Hettiarachchi, Priyadarshika Prathapan, Shamini Sweet taste sensitivity in pre-diabetics, diabetics and normoglycemic controls: a comparative cross sectional study |
title | Sweet taste sensitivity in pre-diabetics, diabetics and normoglycemic controls: a comparative cross sectional study |
title_full | Sweet taste sensitivity in pre-diabetics, diabetics and normoglycemic controls: a comparative cross sectional study |
title_fullStr | Sweet taste sensitivity in pre-diabetics, diabetics and normoglycemic controls: a comparative cross sectional study |
title_full_unstemmed | Sweet taste sensitivity in pre-diabetics, diabetics and normoglycemic controls: a comparative cross sectional study |
title_short | Sweet taste sensitivity in pre-diabetics, diabetics and normoglycemic controls: a comparative cross sectional study |
title_sort | sweet taste sensitivity in pre-diabetics, diabetics and normoglycemic controls: a comparative cross sectional study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146442/ https://www.ncbi.nlm.nih.gov/pubmed/25123551 http://dx.doi.org/10.1186/1472-6823-14-67 |
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