Statistical Power Calculations for Mixed Pharmacokinetic Study Designs Using a Population Approach

Simultaneous modelling of dense and sparse pharmacokinetic data is possible with a population approach. To determine the number of individuals required to detect the effect of a covariate, simulation-based power calculation methodologies can be employed. The Monte Carlo Mapped Power method (a simula...

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Detalles Bibliográficos
Autores principales: Kloprogge, Frank, Simpson, Julie A., Day, Nicholas P. J., White, Nicholas J., Tarning, Joel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147042/
https://www.ncbi.nlm.nih.gov/pubmed/25011414
http://dx.doi.org/10.1208/s12248-014-9641-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147042/
https://www.ncbi.nlm.nih.gov/pubmed/25011414
http://dx.doi.org/10.1208/s12248-014-9641-4

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