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An Investigation on Mitochondrial DNA Deletions and Telomere Shortening during Multiple Passages of Adult Stem Cells

BACKGROUND: Limited resources for adult stem cells necessitate their in vitro culture prior to clinical use. Investigating mitochondrial DNA (mtDNA) and telomere shortening has proved to be important indications of stem cell validity. This study was designed to investigate these indicators in multip...

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Detalles Bibliográficos
Autores principales: Fesahat, Farzaneh, Sheikhha, Mohammad Hasan, Rasti, Azam, Nodoshan, Fatemeh Sadeghian, Zare-Zardini, Hadi, Navabazam, Ali Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Avicenna Research Institute 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147102/
https://www.ncbi.nlm.nih.gov/pubmed/25215179