Combined BRAF(V600E)- and SRC-inhibition induces apoptosis, evokes an immune response and reduces tumor growth in an immunocompetent orthotopic mouse model of anaplastic thyroid cancer

Anaplastic (ATC) and refractory papillary thyroid cancer (PTC) lack effective treatments. Inhibition of either oncogenic BRAF or SRC has marked anti-tumor effects in mouse models of thyroid cancer, however, neither drug induces notable apoptosis. Here we report that the SRC-inhibitor dasatinib furth...

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Detalles Bibliográficos
Autores principales: Borre, Pierre Vanden, Gunda, Viswanath, McFadden, David G., Sadow, Peter M., Varmeh, Shohreh, Bernasconi, Maria, Parangi, Sareh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147301/
https://www.ncbi.nlm.nih.gov/pubmed/24994118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147301/
https://www.ncbi.nlm.nih.gov/pubmed/24994118

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