The poison oligonucleotide F10 is highly effective against acute lymphoblastic leukemia while sparing normal hematopoietic cells

F10 is an oligonucleotide based on the thymidylate synthase (TS) inhibitory 5-fluorouracil (5-FU) metabolite, 5-fluoro-2'-deoxyuridine-5'-O-monophosphate. We sought to determine the activity of F10 against preclinical models of acute lymphoblastic leukemia (ALL). F10 treatment resulted in...

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Detalles Bibliográficos
Autores principales: Pardee, Timothy S., Stadelman, Kristin, Jennings-Gee, Jamie, Caudell, David L., Gmeiner, William H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147314/
https://www.ncbi.nlm.nih.gov/pubmed/24961587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147314/
https://www.ncbi.nlm.nih.gov/pubmed/24961587

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