Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3

The anti-leukemic activity of the mitochondria-targeting small molecule sodium dichloroacetate (DCA), used alone and in association with the small molecule inhibitor of the p53/MDM2 interaction Nutlin-3, was analyzed in primary B-chronic lymphocytic leukemia (B-CLL) samples (n=22), normal peripheral...

Descripción completa

Detalles Bibliográficos
Autores principales: Agnoletto, Chiara, Melloni, Elisabetta, Casciano, Fabio, Rigolin, Gian Matteo, Rimondi, Erika, Celeghini, Claudio, Brunelli, Laura, Cuneo, Antonio, Secchiero, Paola, Zauli, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147328/
https://www.ncbi.nlm.nih.gov/pubmed/24962518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147328/
https://www.ncbi.nlm.nih.gov/pubmed/24962518

Ejemplares similares