Disseminated Bacillus Calmette Guerin Disease in a Twin Infant with Severe Combined Immunodeficiency Disease

Fatal-disseminated Bacillus Calmette Guerin (BCG) disease is well known in infants with severe combined immunodeficiency after BCG vaccination. We report a 7 month male infant delivered as a product of in vitro fertilization and twin gestation that presented with fever, cough and multiple nodular sk...

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Autores principales: Mittal, Hema, Faridi, MMA, Kumar, Pankaj, Aggarwal, Anju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147425/
https://www.ncbi.nlm.nih.gov/pubmed/25191057
http://dx.doi.org/10.4103/0974-777X.138514
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author Mittal, Hema
Faridi, MMA
Kumar, Pankaj
Aggarwal, Anju
author_facet Mittal, Hema
Faridi, MMA
Kumar, Pankaj
Aggarwal, Anju
author_sort Mittal, Hema
collection PubMed
description Fatal-disseminated Bacillus Calmette Guerin (BCG) disease is well known in infants with severe combined immunodeficiency after BCG vaccination. We report a 7 month male infant delivered as a product of in vitro fertilization and twin gestation that presented with fever, cough and multiple nodular skin lesions. A biopsy of skin lesions revealed the presence of acid fast bacilli. Mycobacterium bovis infection was confirmed by polymerase chain reaction (PCR) and molecular studies. Immunological profile confirmed the diagnosis of severe combined immunodeficiency. Only few reports of similar case exist in the literature.
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spelling pubmed-41474252014-09-04 Disseminated Bacillus Calmette Guerin Disease in a Twin Infant with Severe Combined Immunodeficiency Disease Mittal, Hema Faridi, MMA Kumar, Pankaj Aggarwal, Anju J Glob Infect Dis Case Report Fatal-disseminated Bacillus Calmette Guerin (BCG) disease is well known in infants with severe combined immunodeficiency after BCG vaccination. We report a 7 month male infant delivered as a product of in vitro fertilization and twin gestation that presented with fever, cough and multiple nodular skin lesions. A biopsy of skin lesions revealed the presence of acid fast bacilli. Mycobacterium bovis infection was confirmed by polymerase chain reaction (PCR) and molecular studies. Immunological profile confirmed the diagnosis of severe combined immunodeficiency. Only few reports of similar case exist in the literature. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4147425/ /pubmed/25191057 http://dx.doi.org/10.4103/0974-777X.138514 Text en Copyright: © Journal of Global Infectious Diseases http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Mittal, Hema
Faridi, MMA
Kumar, Pankaj
Aggarwal, Anju
Disseminated Bacillus Calmette Guerin Disease in a Twin Infant with Severe Combined Immunodeficiency Disease
title Disseminated Bacillus Calmette Guerin Disease in a Twin Infant with Severe Combined Immunodeficiency Disease
title_full Disseminated Bacillus Calmette Guerin Disease in a Twin Infant with Severe Combined Immunodeficiency Disease
title_fullStr Disseminated Bacillus Calmette Guerin Disease in a Twin Infant with Severe Combined Immunodeficiency Disease
title_full_unstemmed Disseminated Bacillus Calmette Guerin Disease in a Twin Infant with Severe Combined Immunodeficiency Disease
title_short Disseminated Bacillus Calmette Guerin Disease in a Twin Infant with Severe Combined Immunodeficiency Disease
title_sort disseminated bacillus calmette guerin disease in a twin infant with severe combined immunodeficiency disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147425/
https://www.ncbi.nlm.nih.gov/pubmed/25191057
http://dx.doi.org/10.4103/0974-777X.138514
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AT kumarpankaj disseminatedbacilluscalmetteguerindiseaseinatwininfantwithseverecombinedimmunodeficiencydisease
AT aggarwalanju disseminatedbacilluscalmetteguerindiseaseinatwininfantwithseverecombinedimmunodeficiencydisease

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