The prognostic value of BRCA1 promoter methylation in early stage triple negative breast cancer

INTRODUCTION: Methylation of the BRCA1 promoter is frequent in triple negative breast cancers (TNBC) and results in a tumor phenotype similar to BRCA1-mutated tumors. BRCA1 mutation-associated cancers are more sensitive to DNA damaging agents as compared to conventional chemotherapy agents. It is no...

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Detalles Bibliográficos
Autores principales: Sharma, Priyanka, Stecklein, Shane R., Kimler, Bruce F., Sethi, Geetika, Petroff, Brian K., Phillips, Teresa A., Tawfik, Ossama W., Godwin, Andrew K., Jensen, Roy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147783/
https://www.ncbi.nlm.nih.gov/pubmed/25177489
http://dx.doi.org/10.7243/2049-7962-3-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147783/
https://www.ncbi.nlm.nih.gov/pubmed/25177489
http://dx.doi.org/10.7243/2049-7962-3-2

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