Ptpn11 Deletion in A Novel Cartilage Cell Causes Metachondromatosis by Activating Hedgehog Signaling

SHP2, encoded by PTPN11, is required for survival, proliferation and differentiation of various cell types(1,2). Germ line activating mutations in PTPN11 cause Noonan Syndrome, while somatic PTPN11 mutations cause childhood myeloproliferative disease and contribute to some solid tumors. Recently, he...

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Detalles Bibliográficos
Autores principales: Yang, Wentian, Wang, Jianguo, Moore, Douglas C., Liang, Haipei, Dooner, Mark, Wu, Qian, Terek, Richard, Chen, Qian, Ehrlich, Michael G., Quesenberry, Peter J., Neel, Benjamin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148013/
https://www.ncbi.nlm.nih.gov/pubmed/23863940
http://dx.doi.org/10.1038/nature12396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148013/
https://www.ncbi.nlm.nih.gov/pubmed/23863940
http://dx.doi.org/10.1038/nature12396

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