Cargando…

Afatinib and its encapsulated polymeric micelles inhibits HER2-overexpressed colorectal tumor cell growth in vitro and in vivo

Colorectal cancer (CRC) is known as a common malignant neoplasm worldwide. The role of EGFR/HER2 in CRC is unclear. Afatinib is an irreversible EGFR/HER2 inhibitor. There were few studies of afatinib on CRC. Here, we investigated the protein levels/expressions of HER2 in sera and tumors from CRC pat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guan, Siao-Syun, Chang, Jungshan, Cheng, Chun-Chia, Luo, Tsai-Yueh, Ho, Ai-Sheng, Wang, Chia-Chi, Wu, Cheng-Tien, Liu, Shing-Hwa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148106/ https://www.ncbi.nlm.nih.gov/pubmed/24947902

Ejemplares similares

Sulfonamide derivative targeting carbonic anhydrase IX as a nuclear imaging probe for colorectal cancer detection in vivo
por: Guan, Siao-Syun, et al.
Publicado: (2015)

Polyethylene glycol-conjugated HER2-targeted peptides as a nuclear imaging probe for HER2-overexpressed gastric cancer detection in vivo
por: Guan, Siao-Syun, et al.
Publicado: (2018)

Blocking heme oxygenase-1 by zinc protoporphyrin reduces tumor hypoxia-mediated VEGF release and inhibits tumor angiogenesis as a potential therapeutic agent against colorectal cancer
por: Cheng, Chun-Chia, et al.
Publicado: (2016)

Novel targeted nuclear imaging agent for gastric cancer diagnosis: glucose-regulated protein 78 binding peptide-guided (111)In-labeled polymeric micelles
por: Cheng, Chun-Chia, et al.
Publicado: (2013)

Indium-111-labeled CD166-targeted peptide as a potential nuclear imaging agent for detecting colorectal cancer stem-like cells in a xenograft mouse model
por: Guan, Siao-Syun, et al.
Publicado: (2020)

C/EBP homologous protein (CHOP) deficiency ameliorates renal fibrosis in unilateral ureteral obstructive kidney disease
por: Liu, Shing-Hwa, et al.
Publicado: (2016)

ATP synthase subunit-β down-regulation aggravates diabetic nephropathy
por: Guan, Siao-Syun, et al.
Publicado: (2015)

Nano-Encapsulation of Mithramycin in Transfersomes and Polymeric Micelles for the Treatment of Sarcomas
por: Estupiñán, Óscar, et al.
Publicado: (2021)

Curcumin-Encapsulated Polymeric Micelles Suppress the Development of Colon Cancer In Vitro and In Vivo
por: Yang, Xi, et al.
Publicado: (2015)

Encapsulation of catalyst in block copolymer micelles for the polymerization of ethylene in aqueous medium
por: Boucher-Jacobs, Camille, et al.
Publicado: (2018)

Polymeric Micelles of Biodegradable Diblock Copolymers: Enhanced Encapsulation of Hydrophobic Drugs
por: Hussein, Yasser H. A., et al.
Publicado: (2018)

Physicochemical, Pharmacokinetic, and Toxicity Evaluation of Soluplus(®) Polymeric Micelles Encapsulating Fenbendazole
por: Jin, Ik Sup, et al.
Publicado: (2020)

Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model
por: Chen, Chang-Mu, et al.
Publicado: (2021)

Therapeutic Effect of Icaritin on Cerebral Ischemia-Reperfusion-Induced Senescence and Apoptosis in an Acute Ischemic Stroke Mouse Model
por: Wu, Cheng-Tien, et al.
Publicado: (2022)

Enhanced proliferation and differentiation of mesenchymal stem cells by astaxanthin-encapsulated polymeric micelles
por: Zhang, Jun, et al.
Publicado: (2019)

Therapeutic and scintigraphic applications of polymeric micelles: combination of chemotherapy and radiotherapy in hepatocellular carcinoma
por: Shih, Ying-Hsia, et al.
Publicado: (2015)

Bioactive Flavonoids Icaritin and Icariin Protect against Cerebral Ischemia–Reperfusion-Associated Apoptosis and Extracellular Matrix Accumulation in an Ischemic Stroke Mouse Model
por: Wu, Cheng-Tien, et al.
Publicado: (2021)

Self-Assembled Supramolecular Micelles Based on Multiple Hydrogen Bonding Motifs for the Encapsulation and Release of Fullerene
por: Huang, Cheng-Wei, et al.
Publicado: (2022)

Mithramycin encapsulated in polymeric micelles by microfluidic technology as novel therapeutic protocol for beta-thalassemia
por: Capretto, Lorenzo, et al.
Publicado: (2012)

Physical and Pharmacokinetic Characterizations of trans-Resveratrol (t-Rev) Encapsulated with Self-Assembling Lecithin-based Mixed Polymeric Micelles (saLMPMs)
por: Li, Tzu-Pin, et al.
Publicado: (2017)

Neutrophil elastase as a diagnostic marker and therapeutic target in colorectal cancers
por: Ho, Ai-Sheng, et al.
Publicado: (2014)

Role of Calbindin-D28k in Diabetes-Associated Advanced Glycation End-Products-Induced Renal Proximal Tubule Cell Injury
por: Huang, Kuo-How, et al.
Publicado: (2019)

Loading‐Dependent Structural Model of Polymeric Micelles Encapsulating Curcumin by Solid‐State NMR Spectroscopy
por: Pöppler, Ann‐Christin, et al.
Publicado: (2019)

Hyaluronic acid-coated polymeric micelles with hydrogen peroxide scavenging to encapsulate statins for alleviating atherosclerosis
por: Mu, Dan, et al.
Publicado: (2020)

Low Intensity Pulsed Ultrasound Prevents Recurrent Ischemic Stroke in a Cerebral Ischemia/Reperfusion Injury Mouse Model via Brain-derived Neurotrophic Factor Induction
por: Wu, Cheng-Tien, et al.
Publicado: (2019)

The pathological role of advanced glycation end products-downregulated heat shock protein 60 in islet β-cell hypertrophy and dysfunction
por: Guan, Siao-Syun, et al.
Publicado: (2016)

The potential of polymeric micelles in the context of glioblastoma therapy
por: Morshed, Ramin A., et al.
Publicado: (2013)

Phase I open-label study of afatinib plus vinorelbine in patients with solid tumours overexpressing EGFR and/or HER2
por: Bahleda, Rastislav, et al.
Publicado: (2018)

Fisetin and polymeric micelles encapsulating fisetin exhibit potent cytotoxic effects towards ovarian cancer cells
por: Xiao, Xue, et al.
Publicado: (2018)

Enhanced Anticancer Activity of 5’-DFUR-PCL-MPEG Polymeric Prodrug Micelles Encapsulating Chemotherapeutic Drugs
por: Sawdon, Alicia J., et al.
Publicado: (2018)

Preparation and Characterization of Capsaicin Encapsulated Polymeric Micelles and Studies of Synergism with Nicotinic Acids as Potential Anticancer Nanomedicines
por: Shamsheer, Rawan, et al.
Publicado: (2023)

Prevention of acute kidney injury by low intensity pulsed ultrasound via anti-inflammation and anti-apoptosis
por: Chiang, Chih-Kang, et al.
Publicado: (2020)

Polymeric Micelles in Cancer Immunotherapy
por: Wan, Zhuoya, et al.
Publicado: (2021)

STAT3 induces G9a to exacerbate HER3 expression for the survival of epidermal growth factor receptor-tyrosine kinase inhibitors in lung cancers
por: Chang, Yi-Fang, et al.
Publicado: (2019)

Encapsulating Halofuginone Hydrobromide in TPGS Polymeric Micelles Enhances Efficacy Against Triple-Negative Breast Cancer Cells
por: Zuo, Runan, et al.
Publicado: (2021)

Preparation and Characterization of Rutin-Encapsulated Polymeric Micelles and Studies of Synergism with Bioactive Benzoic Acids and Triazolofluoroquinolones as Anticancer Nanomedicines
por: Ibrahim, Razan, et al.
Publicado: (2023)

A Review of Polymeric Micelles and Their Applications
por: Perumal, Suguna, et al.
Publicado: (2022)

Multifunctional Polymeric Micelles for Cancer Therapy
por: Jin, Geun-Woo, et al.
Publicado: (2022)

RGD peptide-mediated chitosan-based polymeric micelles targeting delivery for integrin-overexpressing tumor cells
por: Cai, Li-Li, et al.
Publicado: (2011)

Encapsulation and Characterization of Nanoemulsions Based on an Anti-oxidative Polymeric Amphiphile for Topical Apigenin Delivery
por: Chou, Tzung-Han, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_n7ric8lf4krqlfv5jhpo3tgrl7