The antihypertension drug doxazosin inhibits tumor growth and angiogenesis by decreasing VEGFR-2/Akt/mTOR signaling and VEGF and HIF-1α expression

Doxazosin is an α1 adrenergic receptor blocker that also exerts antitumor effects. However, the underlying mechanisms by which it modulates PI3K/Akt intracellular signaling are poorly understood. In this study, we reveal that doxazosin functions as a novel antiangiogenic agent by inhibiting vascular...

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Detalles Bibliográficos
Autores principales: Park, Mi Sun, Kim, Boh-Ram, Dong, Seung Myung, Lee, Seung-Hoon, Kim, Dae-Yong, Rho, Seung Bae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148112/
https://www.ncbi.nlm.nih.gov/pubmed/24952732

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148112/
https://www.ncbi.nlm.nih.gov/pubmed/24952732

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