Engineered ubiquitin ligase PTB-U-box targets insulin/insulin-like growth factor receptor for degradation and coordinately inhibits cancer malignancy

The type 1 insulin-like growth factor receptor (IGF-1R) is a promising target for cancer therapy with antibodies and small molecule tyrosine kinase inhibitors (TKIs) which have been actively tested clinically. Evidences have demonstrated that insulin receptor (IR), which is implicated in tumorigenes...

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Detalles Bibliográficos
Autores principales: Wang, Qinhao, Ru, Yi, Zhong, Daixing, Zhang, Jing, Yao, Libo, Li, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148113/
https://www.ncbi.nlm.nih.gov/pubmed/24970814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148113/
https://www.ncbi.nlm.nih.gov/pubmed/24970814

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