Insights from yeast into whether the rapamycin inhibition of heat shock transcription factor (Hsf1) can prevent the Hsf1 activation that results from treatment with an Hsp90 inhibitor

In human cells TORC1 mTOR (target of rapamycin) protein kinase complex renders heat shock transcription factor 1 (Hsf1) competent for stress activation. In such cells, as well as in yeast, the selective TORC1 inhibitor rapamycin blocks this activation in contrast to Hsp90 inhibitors which potently a...

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Detalles Bibliográficos
Autores principales: Millson, Stefan H., Piper, Peter W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148121/
https://www.ncbi.nlm.nih.gov/pubmed/24970820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148121/
https://www.ncbi.nlm.nih.gov/pubmed/24970820

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