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Pulsed Electron Paramagnetic Resonance Study of Domain Docking in Neuronal Nitric Oxide Synthase: The Calmodulin and Output State Perspective

[Image: see text] The binding of calmodulin (CaM) to neuronal nitric oxide synthase (nNOS) enables formation of the output state of nNOS for nitric oxide production. Essential to NOS function is the geometry and dynamics of CaM docking to the NOS oxygenase domain, but little is known about these det...

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Detalles Bibliográficos
Autores principales: Astashkin, Andrei V., Chen, Li, Zhou, Xixi, Li, Huiying, Poulos, Thomas L., Liu, Ke Jian, Guillemette, J. Guy, Feng, Changjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148148/
https://www.ncbi.nlm.nih.gov/pubmed/25046446
http://dx.doi.org/10.1021/jp503547w