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Successes and Challenges in Phenotype-Based Lead Discovery for Prion Diseases: Miniperspective
[Image: see text] Creutzfeldt–Jakob disease (CJD) is a rare but invariably fatal neurodegenerative disease caused by misfolding of an endogenous protein into an alternative pathogenic conformation. The details of protein misfolding and aggregation are not well understood nor are the mechanism(s) by...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148153/ https://www.ncbi.nlm.nih.gov/pubmed/24762293 http://dx.doi.org/10.1021/jm5001425 |