UNC2025, a Potent and Orally Bioavailable MER/FLT3 Dual Inhibitor

[Image: see text] We previously reported a potent small molecule Mer tyrosine kinase inhibitor UNC1062. However, its poor PK properties prevented further assessment in vivo. We report here the sequential modification of UNC1062 to address DMPK properties and yield a new potent and highly orally bioa...

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Detalles Bibliográficos
Autores principales: Zhang, Weihe, DeRyckere, Deborah, Hunter, Debra, Liu, Jing, Stashko, Michael A., Minson, Katherine A., Cummings, Christopher T., Lee, Minjung, Glaros, Trevor G., Newton, Dianne L., Sather, Susan, Zhang, Dehui, Kireev, Dmitri, Janzen, William P., Earp, H. Shelton, Graham, Douglas K., Frye, Stephen V., Wang, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148167/
https://www.ncbi.nlm.nih.gov/pubmed/25068800
http://dx.doi.org/10.1021/jm500749d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148167/
https://www.ncbi.nlm.nih.gov/pubmed/25068800
http://dx.doi.org/10.1021/jm500749d

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