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A marked paucity of granule cells in the developing cerebellum of the Npc1(−/−) mouse is corrected by a single injection of hydroxypropyl-β-cyclodextrin
In this study we show that postnatal development of cerebellar granule neurons (GNs) is defective in Npc1(−/−) mice. Compared to age-matched wild-type littermates, there is an accelerated disappearance of the external granule layer (EGL) in these mice. This is due to a premature exit from the cell c...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Academic Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148175/ https://www.ncbi.nlm.nih.gov/pubmed/24969023 http://dx.doi.org/10.1016/j.nbd.2014.06.012 |