Hypoxia-induced Bmi1 promotes renal tubular epithelial cell–mesenchymal transition and renal fibrosis via PI3K/Akt signal

Hypoxia is an important microenvironmental factor in the development of renal fibrosis; however, the underlying mechanisms are not well elucidated. Here we show that hypoxia induces Bmi1 mRNA and protein expression in human tubular epithelial cells. We further demonstrate that Bmi1 expression might...

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Detalles Bibliográficos
Autores principales: Du, Rui, Xia, Lin, Ning, Xiaoxuan, Liu, Limin, Sun, Wenjuan, Huang, Chen, Wang, Hanmin, Sun, Shiren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148254/
https://www.ncbi.nlm.nih.gov/pubmed/25009285
http://dx.doi.org/10.1091/mbc.E14-01-0044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148254/
https://www.ncbi.nlm.nih.gov/pubmed/25009285
http://dx.doi.org/10.1091/mbc.E14-01-0044

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