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Hypoxia Promotes Uveal Melanoma Invasion through Enhanced Notch and MAPK Activation
The transcriptional response promoted by hypoxia-inducible factors has been associated with metastatic spread of uveal melanoma. We found expression of hypoxia-inducible factor 1α (HIF-1α) protein in well-vascularized tumor regions as well as in four cell lines grown in normoxia, thus this pathway m...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148307/ https://www.ncbi.nlm.nih.gov/pubmed/25166211 http://dx.doi.org/10.1371/journal.pone.0105372 |