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Hypoxia Promotes Uveal Melanoma Invasion through Enhanced Notch and MAPK Activation

The transcriptional response promoted by hypoxia-inducible factors has been associated with metastatic spread of uveal melanoma. We found expression of hypoxia-inducible factor 1α (HIF-1α) protein in well-vascularized tumor regions as well as in four cell lines grown in normoxia, thus this pathway m...

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Detalles Bibliográficos
Autores principales:	Asnaghi, Laura, Lin, Michael H., Lim, Kah Suan, Lim, Kah Jing, Tripathy, Arushi, Wendeborn, Murilo, Merbs, Shannath L., Handa, James T., Sodhi, Akrit, Bar, Eli E., Eberhart, Charles G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148307/ https://www.ncbi.nlm.nih.gov/pubmed/25166211 http://dx.doi.org/10.1371/journal.pone.0105372

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