SphK1 confers resistance to apoptosis in gastric cancer cells by downregulating Bim via stimulating Akt/FoxO3a signaling

We previously reported that sphingosine kinase 1 (SphK1), an enzyme that catalyzes the production of sphingosine- 1-phosphate (SIP), is upregulated in human gastric cancer and predicts poor clinical outcome. In the present study, we used known differential effects of UV irradiation on human MGC-803...

Descripción completa

Detalles Bibliográficos
Autores principales: XIONG, HUAPING, WANG, JICHENG, GUAN, HONGYU, WU, JUEHENG, XU, RU, WANG, MIN, RONG, XIA, HUANG, KE, HUANG, JIETING, LIAO, QIAO, FU, YONGSHUI, YUAN, JIE
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148362/
https://www.ncbi.nlm.nih.gov/pubmed/25109605
http://dx.doi.org/10.3892/or.2014.3391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148362/
https://www.ncbi.nlm.nih.gov/pubmed/25109605
http://dx.doi.org/10.3892/or.2014.3391

Ejemplares similares