Overexpression of Mitochondrial Sirtuins Alters Glycolysis and Mitochondrial Function in HEK293 Cells

SIRT3, SIRT4, and SIRT5 are mitochondrial deacylases that impact multiple facets of energy metabolism and mitochondrial function. SIRT3 activates several mitochondrial enzymes, SIRT4 represses its targets, and SIRT5 has been shown to both activate and repress mitochondrial enzymes. To gain insight i...

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Detalles Bibliográficos
Autores principales: Barbi de Moura, Michelle, Uppala, Radha, Zhang, Yuxun, Van Houten, Bennett, Goetzman, Eric S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148395/
https://www.ncbi.nlm.nih.gov/pubmed/25165814
http://dx.doi.org/10.1371/journal.pone.0106028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148395/
https://www.ncbi.nlm.nih.gov/pubmed/25165814
http://dx.doi.org/10.1371/journal.pone.0106028

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