Cargando…

Primary Seronegative but Molecularly Evident Hepadnaviral Infection Engages Liver and Induces Hepatocarcinoma in the Woodchuck Model of Hepatitis B

Hepadnavirus at very low doses establishes in woodchucks asymptomatic, serologically undetectable but molecularly evident persistent infection. This primary occult infection (POI) preferentially engages the immune system and initiates virus-specific T cell response in the absence of antiviral antibo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mulrooney-Cousins, Patricia M., Chauhan, Ranjit, Churchill, Norma D., Michalak, Tomasz I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148403/ https://www.ncbi.nlm.nih.gov/pubmed/25165821 http://dx.doi.org/10.1371/journal.ppat.1004332

Ejemplares similares

Asymptomatic Hepadnaviral Persistence and Its Consequences in the Woodchuck Model of Occult Hepatitis B Virus Infection
por: Mulrooney-Cousins, Patricia M., et al.
Publicado: (2015)

Hepadnaviral Lymphotropism and Its Relevance to HBV Persistence and Pathogenesis
por: Coffin, Carla S., et al.
Publicado: (2021)

Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinoma
por: Chauhan, R, et al.
Publicado: (2017)

Identification of antibodies cross-reactive with woodchuck immune cells and activation of virus-specific and global cytotoxic T cell responses by anti-PD-1 and anti-PD-L1 in experimental chronic hepatitis B and persistent occult hepadnaviral infection
por: Corkum, Christopher P., et al.
Publicado: (2022)

Differential Expression of Woodchuck Toll-Like Receptors 1–10 in Distinct Forms of Infection and Stages of Hepatitis in Experimental Hepatitis B Virus Infection
por: Williams, John Bradley, et al.
Publicado: (2018)

Enzyme‐altered Liver Cell Foci in Woodchucks Infected with Woodchuck Hepatitis Virus
por: Abe, Kenji, et al.
Publicado: (1988)

Molecular characterization of woodchuck IFI16 and AIM2 and their expression in woodchucks infected with woodchuck hepatitis virus (WHV)
por: Yan, Qi, et al.
Publicado: (2016)

Diverse Virus and Host-Dependent Mechanisms Influence the Systemic and Intrahepatic Immune Responses in the Woodchuck Model of Hepatitis B
por: Michalak, Tomasz I.
Publicado: (2020)

Innate and adaptive immunity associated with resolution of acute woodchuck hepatitis virus infection in adult woodchucks
por: Suresh, Manasa, et al.
Publicado: (2019)

Efficacy of an Inhibitor of Hepatitis B Virus Expression in Combination With Entecavir and Interferon‐α in Woodchucks Chronically Infected With Woodchuck Hepatitis Virus
por: Menne, Stephan, et al.
Publicado: (2020)

Combination Treatment with the Vimentin-Targeting Antibody hzVSF and Tenofovir Suppresses Woodchuck Hepatitis Virus Infection in Woodchucks
por: Korolowicz, Kyle E., et al.
Publicado: (2021)

Ancient evolution of hepadnaviral paleoviruses and their impact on host genomes
por: Lytras, Spyros, et al.
Publicado: (2021)

Application of the woodchuck animal model for the treatment of hepatitis B virus-induced liver cancer
por: Suresh, Manasa, et al.
Publicado: (2021)

Therapeutic Vaccination in Chronic Hepatitis B: Preclinical Studies in the Woodchuck
por: Kosinska, Anna D., et al.
Publicado: (2010)

Persistence of the Recombinant Genomes of Woodchuck Hepatitis Virus in the Mouse Model
por: Pan, Danzhen, et al.
Publicado: (2015)

Imaging, Pathology, and Immune Correlates in the Woodchuck Hepatic Tumor Model
por: Mauda-Havakuk, Michal, et al.
Publicado: (2021)

Recent Drug Development in the Woodchuck Model of Chronic Hepatitis B
por: Suresh, Manasa, et al.
Publicado: (2022)

Involvement of Innate Immune Receptors in the Resolution of Acute Hepatitis B in Woodchucks
por: Suresh, Manasa, et al.
Publicado: (2021)

Therapeutic vaccination and immunomodulation in the treatment of chronic hepatitis B: preclinical studies in the woodchuck
por: Kosinska, Anna D., et al.
Publicado: (2014)

A241 CHARACTERIZING KUPFFER CELL-VIRUS INTERACTIONS IMMEDIATELY FOLLOWING VIRAL INVASION AND IN ACUTE HEPATITIS IN THE WOODCHUCK HEPATITIS VIRUS MODEL OF HEPATITIS B VIRUS INFECTIONS
por: Al-Yasiri, L, et al.
Publicado: (2023)

Immune Effects of Cryoablation in Woodchuck Hepatocellular Carcinoma
por: Mauda-Havakuk, Michal, et al.
Publicado: (2023)

Seronegative Autoimmune Hepatitis
por: Bhumi, Sriya A., et al.
Publicado: (2023)

Cryo-EM structures of human hepatitis B and woodchuck hepatitis virus small spherical subviral particles
por: Liu, Haitao, et al.
Publicado: (2022)

Role of Cell-Penetrating Peptides in Intracellular Delivery of Peptide Nucleic Acids Targeting Hepadnaviral Replication
por: Ndeboko, Bénédicte, et al.
Publicado: (2017)

Multicystic Hepatocarcinoma Mimicking Liver Abscess
por: Falidas, Evangelos, et al.
Publicado: (2013)

Seronegative autoimmune hepatitis in childhood
por: Islek, Ali, et al.
Publicado: (2023)

Translation of stable hepadnaviral mRNA cleavage fragments induced by the action of phosphorothioate-modified antisense oligodeoxynucleotides
por: Hasselblatt, Peter, et al.
Publicado: (2005)

Disturbances in the Glutathione/Ophthalmate Redox Buffer System in the Woodchuck Model of Hepatitis Virus-Induced Hepatocellular Carcinoma
por: Andres Ibarra, Rafael, et al.
Publicado: (2011)

AIC649 Induces a Bi-Phasic Treatment Response in the Woodchuck Model of Chronic Hepatitis B
por: Paulsen, Daniela, et al.
Publicado: (2015)

Intrahepatic Transcriptional Signature Associated with Response to Interferon-α Treatment in the Woodchuck Model of Chronic Hepatitis B
por: Fletcher, Simon P., et al.
Publicado: (2015)

The Genome Sequence of the Eastern Woodchuck (Marmota monax) – A Preclinical Animal Model for Chronic Hepatitis B
por: Alioto, Tyler S., et al.
Publicado: (2019)

A novel hepatovirus identified in wild woodchuck Marmota himalayana
por: Yu, Jie-mei, et al.
Publicado: (2016)

Constrained evolution of overlapping genes in viral host adaptation: Acquisition of glycosylation motifs in hepadnaviral precore/core genes
por: Hong, Xupeng, et al.
Publicado: (2022)

Liver‐Targeted Toll‐Like Receptor 7 Agonist Combined With Entecavir Promotes a Functional Cure in the Woodchuck Model of Hepatitis B Virus
por: Korolowizc, Kyle E., et al.
Publicado: (2019)

Prevention of liver tumor formation in woodchucks with established hepatocellular carcinoma by treatment with cationic liposome-DNA complexes
por: Fairman, Jeffery, et al.
Publicado: (2017)

Agonistic Activation of Cytosolic DNA Sensing Receptors in Woodchuck Hepatocyte Cultures and Liver for Inducing Antiviral Effects
por: Suresh, Manasa, et al.
Publicado: (2021)

Reactivation of hepatitis B after liver transplantation: Current knowledge, molecular mechanisms and implications in management
por: Chauhan, Ranjit, et al.
Publicado: (2018)

Seronegative Hepatitis C Virus Infection
por: Kaźmierczak, Justyna, et al.
Publicado: (2013)

The Expression of PD-1 Ligands and Their Involvement in Regulation of T Cell Functions in Acute and Chronic Woodchuck Hepatitis Virus Infection
por: Zhang, Ejuan, et al.
Publicado: (2011)

Correction: Intrahepatic Transcriptional Signature Associated with Response to Interferon-α Treatment in the Woodchuck Model of Chronic Hepatitis B
por: Fletcher, Simon P., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_66jccot2l5jco4tqql2rjisr5v