The Histone Deacetylase Inhibitor, Vorinostat, Represses Hypoxia Inducible Factor 1 Alpha Expression through Translational Inhibition

Hypoxia inducible factor 1α (HIF-1α) is a master regulator of tumor angiogenesis being one of the major targets for cancer therapy. Previous studies have shown that Histone Deacetylase Inhibitors (HDACi) block tumor angiogenesis through the inhibition of HIF-1α expression. As such, Vorinostat (Suber...

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Detalles Bibliográficos
Autores principales: Hutt, Darren M., Roth, Daniela Martino, Vignaud, Hélène, Cullin, Christophe, Bouchecareilh, Marion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148404/
https://www.ncbi.nlm.nih.gov/pubmed/25166596
http://dx.doi.org/10.1371/journal.pone.0106224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148404/
https://www.ncbi.nlm.nih.gov/pubmed/25166596
http://dx.doi.org/10.1371/journal.pone.0106224

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