Relationship between Poor Immunogenicity of HLA-A2-Restricted Peptide Epitopes and Paucity of Naïve CD8(+) T-Cell Precursors in HLA-A2-Transgenic Mice

We examined the immunogenicity of H-2 class I-restricted and HLA-A2-restricted epitopes through peptide immunization of HLA-A2-transgenic mice that also express mouse H-2 class I molecules. All four of the tested epitopes restricted by H-2 class I robustly elicited T-cell responses, but four of seve...

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Detalles Bibliográficos
Autores principales: Choi, Yoon Seok, Lee, Dong Ho, Shin, Eui-Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2014
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148492/
https://www.ncbi.nlm.nih.gov/pubmed/25177254
http://dx.doi.org/10.4110/in.2014.14.4.219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148492/
https://www.ncbi.nlm.nih.gov/pubmed/25177254
http://dx.doi.org/10.4110/in.2014.14.4.219

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