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The tyrosine phosphatase Ptpn22 discriminates weak, self-peptide from strong agonist T cell receptor signals
T cells must be tolerant of self-antigens to avoid autoimmunity, but responsive to foreign-antigens to provide protection against infection. We found that in both naive and effector T cells, the tyrosine phosphatase, Ptpn22 limits T cell receptor signaling by weak agonist and self-antigens, while no...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148831/ https://www.ncbi.nlm.nih.gov/pubmed/25108421 http://dx.doi.org/10.1038/ni.2958 |