Substitution of the premembrane and envelope protein genes of Modoc virus with the homologous sequences of West Nile virus generates a chimeric virus that replicates in vertebrate but not mosquito cells

BACKGROUND: Most known flaviviruses, including West Nile virus (WNV), are maintained in natural transmission cycles between hematophagous arthropods and vertebrate hosts. Other flaviviruses such as Modoc virus (MODV) and Culex flavivirus (CxFV) have host ranges restricted to vertebrates and insects,...

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Detalles Bibliográficos
Autores principales: Saiyasombat, Rungrat, Carrillo-Tripp, Jimena, Miller, Wyatt Allen, Bredenbeek, Peter J, Blitvich, Bradley J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148964/
https://www.ncbi.nlm.nih.gov/pubmed/25151534
http://dx.doi.org/10.1186/1743-422X-11-150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148964/
https://www.ncbi.nlm.nih.gov/pubmed/25151534
http://dx.doi.org/10.1186/1743-422X-11-150

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