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Rapid, repeated, low-dose challenges with SIVmac239 infect animals in a condensed challenge window

BACKGROUND: Simian immunodeficiency virus (SIV) infection of nonhuman primates is the predominant model for preclinical evaluation of human immunodeficiency virus (HIV) vaccines. These studies frequently utilize high-doses of SIV that ensure infection after a single challenge but do not recapitulate...

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Detalles Bibliográficos
Autores principales: Greene, Justin M, Weiler, Andrea M, Reynolds, Matthew R, Cain, Brian T, Pham, Ngoc H, Ericsen, Adam J, Peterson, Eric J, Crosno, Kristin, Brunner, Kevin, Friedrich, Thomas C, O’Connor, David H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149191/
https://www.ncbi.nlm.nih.gov/pubmed/25125288
http://dx.doi.org/10.1186/s12977-014-0066-z