Cardiac Overexpression of Constitutively Active Galpha q Causes Angiotensin II Type1 Receptor Activation, Leading to Progressive Heart Failure and Ventricular Arrhythmias in Transgenic Mice

BACKGROUND: Transgenic mice with transient cardiac expression of constitutively active Galpha q (Gα(q)-TG) exhibt progressive heart failure and ventricular arrhythmias after the initiating stimulus of transfected constitutively active Gα(q) becomes undetectable. However, the mechanisms are still unk...

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Detalles Bibliográficos
Autores principales: Matsushita, Naoko, Kashihara, Toshihide, Shimojo, Hisashi, Suzuki, Satoshi, Nakada, Tsutomu, Takeishi, Yasuchika, Mende, Ulrike, Taira, Eiichi, Yamada, Mitsuhiko, Sanbe, Atsushi, Hirose, Masamichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149533/
https://www.ncbi.nlm.nih.gov/pubmed/25171374
http://dx.doi.org/10.1371/journal.pone.0106354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149533/
https://www.ncbi.nlm.nih.gov/pubmed/25171374
http://dx.doi.org/10.1371/journal.pone.0106354

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