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133 Structural basis for ebolavirus matrix assembly and budding; protein plasticity allows multiple functions

Proteins, particularly viral proteins, can be multifunctional, but the mechanism(s) behind this trait are not fully understood. Here, we illustrate through multiple crystal structures, biochemistry and cellular microscopy that the Ebola virus VP40 protein rearranges into different structures, each w...

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Detalles Bibliográficos
Autores principales: Bornholdt, Zachary, Noda, Takeshi, Abelson, Dafna, Halfmann, Peter, Wood, Malcolm, Kawaoa, Yoshihiro, Saphire, Erica Ollmann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JAIDS Journal of Acquired Immune Deficiency Syndromes 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149652/
http://dx.doi.org/10.1097/01.qai.0000446713.32982.25