Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters

An enigma in the field of peptide transport is the structural basis for ligand promiscuity, as exemplified by PepT1, the mammalian plasma membrane peptide transporter. Here, we present crystal structures of di- and tripeptide-bound complexes of a bacterial homologue of PepT1, which reveal at least t...

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Detalles Bibliográficos
Autores principales: Lyons, Joseph A, Parker, Joanne L, Solcan, Nicolae, Brinth, Alette, Li, Dianfan, Shah, Syed TA, Caffrey, Martin, Newstead, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Scientific Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149780/
https://www.ncbi.nlm.nih.gov/pubmed/24916388
http://dx.doi.org/10.15252/embr.201338403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149780/
https://www.ncbi.nlm.nih.gov/pubmed/24916388
http://dx.doi.org/10.15252/embr.201338403

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