Cargando…

Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters

An enigma in the field of peptide transport is the structural basis for ligand promiscuity, as exemplified by PepT1, the mammalian plasma membrane peptide transporter. Here, we present crystal structures of di- and tripeptide-bound complexes of a bacterial homologue of PepT1, which reveal at least t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lyons, Joseph A, Parker, Joanne L, Solcan, Nicolae, Brinth, Alette, Li, Dianfan, Shah, Syed TA, Caffrey, Martin, Newstead, Simon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Scientific Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149780/ https://www.ncbi.nlm.nih.gov/pubmed/24916388 http://dx.doi.org/10.15252/embr.201338403

Ejemplares similares

Proton movement and coupling in the POT family of peptide transporters
por: Parker, Joanne L., et al.
Publicado: (2017)

Gating Topology of the Proton-Coupled Oligopeptide Symporters
por: Fowler, Philip W., et al.
Publicado: (2015)

Alternating access mechanism in the POT family of oligopeptide transporters
por: Solcan, Nicolae, et al.
Publicado: (2012)

Molecular insights into proton coupled peptide transport in the PTR family of oligopeptide transporters()
por: Newstead, Simon
Publicado: (2015)

Accurate Prediction of Ligand Affinities for a Proton-Dependent Oligopeptide Transporter
por: Samsudin, Firdaus, et al.
Publicado: (2016)

Structural basis for proton coupled cystine transport by cystinosin
por: Löbel, Mark, et al.
Publicado: (2022)

Molecular basis of polyspecific drug binding and transport by OCT1 and OCT2
por: Suo, Yang, et al.
Publicado: (2023)

Structural basis for prodrug recognition by the SLC15 family of proton-coupled peptide transporters
por: Minhas, Gurdeep S., et al.
Publicado: (2019)

Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals
por: Parker, Joanne L., et al.
Publicado: (2021)

Characterization of murine polyspecific monoamine transporters
por: Miura, Yamato, et al.
Publicado: (2017)

OCT1 Polyspecificity—Friend or Foe?
por: Meyer, Marleen J., et al.
Publicado: (2021)

Thermodynamic evidence for a dual transport mechanism in a POT peptide transporter
por: Parker, Joanne L, et al.
Publicado: (2014)

Structural basis of nucleotide sugar transport across the Golgi membrane
por: Parker, Joanne L, et al.
Publicado: (2017)

A conformational landscape for alginate secretion across the outer membrane of Pseudomonas aeruginosa
por: Tan, Jingquan, et al.
Publicado: (2014)

Expression and Regulation of the Proton-Coupled Oligopeptide Transporter PhT2 by LPS in Macrophages and Mouse Spleen
por: Wang, Yuqing, et al.
Publicado: (2014)

Analysing the substrate multispecificity of a proton-coupled oligopeptide transporter using a dipeptide library
por: Ito, Keisuke, et al.
Publicado: (2013)

Molecular Insights to the Structure-Interaction Relationships of Human Proton-Coupled Oligopeptide Transporters (PepTs)
por: Luo, Yining, et al.
Publicado: (2023)

Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor
por: Diakogiannaki, Eleftheria, et al.
Publicado: (2013)

Molecular basis of nitrate uptake by the plant nitrate transporter NRT1.1
por: Parker, Joanne L., et al.
Publicado: (2014)

Polyspecificity of antistreptococcal murine monoclonal antibodies and their implications in autoimmunity
Publicado: (1986)

Tripeptide binding in a proton‐dependent oligopeptide transporter
por: Martinez Molledo, Maria, et al.
Publicado: (2018)

Polyspecific monoclonal lupus autoantibodies reactive with both polynucleotides and phospholipids
Publicado: (1981)

Human Germline Antibody Gene Segments Encode Polyspecific Antibodies
por: Willis, Jordan R., et al.
Publicado: (2013)

A simple mathematical approach to the analysis of polypharmacology and polyspecificity data
por: Maggiora, Gerry, et al.
Publicado: (2017)

Evaluation of IgY Antibody as a Polyspecific Coombs-Reagent
por: Calzado, Esteban Justo Gutiérrez, et al.
Publicado: (2017)

Structural definition of polyspecific compensatory ligand recognition by P-glycoprotein
por: Le, Christina A., et al.
Publicado: (2020)

Transport Deficiency Is the Molecular Basis of Candida albicans Resistance to Antifungal Oligopeptides
por: Schielmann, Marta, et al.
Publicado: (2017)

Probing the Putative Active Site of YjdL: An Unusual Proton-Coupled Oligopeptide Transporter from E. coli
por: Jensen, Johanne Mørch, et al.
Publicado: (2012)

Multispecific Substrate Recognition in a Proton-Dependent Oligopeptide Transporter
por: Martinez Molledo, Maria, et al.
Publicado: (2018)

Structural basis for amino acid transport by the CAT family of SLC7 transporters
por: Jungnickel, Katharina E. J., et al.
Publicado: (2018)

Specific expression of proton-coupled oligopeptide transporter 1 in primary hepatocarcinoma-a novel strategy for tumor-targeted therapy
por: Gong, Yanxia, et al.
Publicado: (2017)

Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse
por: Kummer, Wolfgang, et al.
Publicado: (2006)

Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer
por: Parker, Joanne L., et al.
Publicado: (2019)

Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1
por: Parker, Joanne L., et al.
Publicado: (2023)

Intrathecal, Polyspecific Antiviral Immune Response in Oligoclonal Band Negative Multiple Sclerosis
por: Brecht, Isabel, et al.
Publicado: (2012)

Emerging consensus on the mechanism of polyspecific substrate recognition by the multidrug transporter P-glycoprotein
por: Xia, Di, et al.
Publicado: (2019)

Recent advances in understanding prodrug transport through the SLC15 family of proton-coupled transporters
por: Minhas, Gurdeep S., et al.
Publicado: (2020)

Interaction of ALK Inhibitors with Polyspecific Organic Cation Transporters and the Impact of Substrate-Dependent Inhibition on the Prediction of Drug–Drug Interactions
por: Tsang, Yik Pui, et al.
Publicado: (2023)

Commodity risk assessment of Berberis thunbergii potted plants from Turkey
por: Bragard, Claude, et al.
Publicado: (2022)

Neuroimmunology: Immunoglobulins and the Intrathecal Polyspecific Immune Response in Acute, Subacute and Chronic Neurological Diseases
por: Reiber, Hansotto
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_4j6hols4h60tm3edshi1v712sh