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Deletion of ErbB4 accelerates polycystic kidney disease progression in cpk mice

ErbB4 is highly expressed in the cystic kidneys with polycystic kidney diseases. To investigate its potential role in cystogenesis, cpk mice carrying a heart-rescued ErbB4 deletion were generated. Accelerated cyst progression and renal function deterioration were noted as early as 10 days postnatall...

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Detalles Bibliográficos
Autores principales: Zeng, Fenghua, Miyazawa, Tomoki, Kloepfer, Lance A., Harris, Raymond C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149866/
https://www.ncbi.nlm.nih.gov/pubmed/24670412
http://dx.doi.org/10.1038/ki.2014.84