p300-mediated acetylation of COMMD1 regulates its stability, and the ubiquitylation and nucleolar translocation of the RelA NF-κB subunit

Nucleolar sequestration of the RelA subunit of nuclear factor (NF)-κB is an important mechanism for regulating NF-κB transcriptional activity. Ubiquitylation, facilitated by COMMD1 (also known as MURR1), acts as a crucial nucleolar-targeting signal for RelA, but how this ubiquitylation is regulated,...

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Detalles Bibliográficos
Autores principales: O'Hara, Andrew, Simpson, James, Morin, Pierre, Loveridge, Carolyn J., Williams, Ann C., Novo, Sonia M., Stark, Lesley A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2014
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150058/
https://www.ncbi.nlm.nih.gov/pubmed/25074812
http://dx.doi.org/10.1242/jcs.149328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150058/
https://www.ncbi.nlm.nih.gov/pubmed/25074812
http://dx.doi.org/10.1242/jcs.149328

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